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Article

A siRNA-based screen for genes involved in chromosome end protection.

PloS one - 1 Jan 2011

Lackner Daniel H, Durocher Daniel, Karlseder Jan

Abstract excerpt

Telomeres are nucleoprotein complexes which protect the ends of linear chromosomes from detection as DNA damage and provide a sequence buffer against replication-associated shortening. In mammals, telomeres consist of repetitive DNA sequence (TTAGGG) and associated proteins. The telomeric core complex is called shelterin and is comprised of the proteins TRF1, TRF2, POT1, TIN2, TPP1 and RAP1. Excessive telomere...

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Source

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Identifiers

PMID: 21760879
DOI: 10.1371/journal.pone.0021407
PMCID: PMC3121770

Genes

POT1
SNW1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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