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Article

Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.

Science signaling - 30 Apr 2013

Idevall-Hagren Olof, Jakobsson Ida, Xu Yunjian, Tengholm Anders

Abstract excerpt

The cAMP (adenosine 3',5'-monophosphate)-activated guanine nucleotide exchange factor (GEF) Epac2 is an important mediator of cAMP-dependent processes in multiple cell types. We used real-time confocal and total internal reflection fluorescence microscopy to examine the spatiotemporal regulation of Epac2, which is a GEF for the guanosine triphosphatase (GTPase) Rap. We demonstrated that increases in the...

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Identifiers

PMID: 23633676
DOI: 10.1126/scisignal.2003932

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Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.PMID 23633676Read ↗

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Rap-Interacting Proteins are Key Players in the Rap Symphony OrchestraSemantic proximity Read ↗

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Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A.Semantic proximity Read ↗

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Semantic proximity Read ↗

Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger.Semantic proximity Read ↗

Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA.Semantic proximity Read ↗

Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.Semantic proximity Read ↗

Structure-Guided Design of Selective Epac1 and Epac2 AgonistsSemantic proximity Read ↗

Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.Semantic proximity Read ↗

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