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Article

Constitutively active protein kinase A disrupts motility and chemotaxis in Dictyostelium discoideum.

Eukaryotic cell - 1 Feb 2003

Zhang Hui, Heid Paul J, Wessels Deborah, Daniels Karla J, Pham Tien, Loomis William F, Soll David R

Abstract excerpt

The deletion of the gene for the regulatory subunit of protein kinase A (PKA) results in constitutively active PKA in the pkaR mutant. To investigate the role of PKA in the basic motile behavior and chemotaxis of Dictyostelium discoideum, pkaR mutant cells were subjected to computer-assisted two- and three-dimensional motion analysis. pkaR mutant cells crawled at only half the speed of wild-type cells in buffer,...

Topics

3',5'-Cyclic-AMP Phosphodiesterases
Animals
Cell Polarity
Cell Size
Chemotaxis
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Dictyostelium
Image Processing, Computer-Assisted
Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protozoan Proteins

Pseudopodia

Source

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Identifiers

PMID: 12582123
DOI: 10.1128/EC.2.1.62-75.2003
PMCID: PMC141174

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