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Article

The LATS2/KPM Tumor Suppressor Is a Negative Regulator of the Androgen Receptor

11 May 2004

Abstract excerpt

The androgen receptor (AR) is a member of the steroid receptor superfamily that plays critical roles in the development and maintenance of the male reproductive system and in prostate cancer. Actions of AR are controlled by interaction with several classes of coregulators. In this study, we have identified LATS2/KPM as a novel AR-interacting protein. Human LATS1 and LATS2 are tumor suppressors that are homologs...

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PMID: 15131260
DOI: 10.1210/me.2004-0065

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