Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.

Oncogene - 22 Aug 2013

Ha S, Iqbal N J, Mita P, Ruoff R, Gerald W L, Lepor H, Taneja S S, Lee P, Melamed J, Garabedian M J, Logan S K

Abstract excerpt

Integration of cellular signaling pathways with androgen receptor (AR) signaling can be achieved through phosphorylation of AR by cellular kinases. However, the kinases responsible for phosphorylating the AR at numerous sites and the functional consequences of AR phosphorylation are only partially understood. Bioinformatic analysis revealed AR serine 213 (S213) as a putative substrate for PIM1, a kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Hormonal
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to Prostate-Specific Antigen

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to Serine

Share to Tissue Array Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 22986532
DOI: 10.1038/onc.2012.412
PMCID: PMC3527659

Genes

PIM1
IGFBP5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.PMID 22986532Read ↗

PIM1 kinase as a target in prostate cancer: roles in tumorigenesis, castration resistance, and docetaxel resistance.Semantic proximity Read ↗

Expression and ERG regulation of PIM kinases in prostate cancerSemantic proximity Read ↗

AR Signaling and the PI3K Pathway in Prostate CancerSemantic proximity Read ↗

Androgen receptor phosphorylation: biological context and functional consequencesSemantic proximity Read ↗

The role of PIM1/PIM2 kinases in tumors of the male reproductive systemSemantic proximity Read ↗

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunitiesSemantic proximity Read ↗

The PIM kinases in hematological cancersSemantic proximity Read ↗

Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeuticsSemantic proximity Read ↗

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.Semantic proximity Read ↗

Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.Semantic proximity Read ↗

PIM1 kinase as a promise of targeted therapy in prostate cancer stem cellsSemantic proximity Read ↗

A review on PIM kinases in tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.