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Article

LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis.

PloS one - 1 Jan 2017

Yu Eun-Jeong, Hooker Erika, Johnson Daniel T, Kwak Mi Kyung, Zou Kang, Luong Richard, He Yongfeng, Sun Zijie

Abstract excerpt

The leucine zipper tumor suppressor 2 (LZTS2) was identified as a tumor susceptibility gene within the 10q24.3 chromosomal region, and is approximately 15Mb from the PTEN locus. This region containing the both loci is frequently deleted in a variety of human malignancies, including prostate cancer. LZTS2 is a ß-catenin-binding protein and a negative regulator of Wnt signaling. Overexpression of PTEN in prostate...

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Share to beta Catenin
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Small Interfering

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Source

Open in PubMed Open full text

Identifiers

PMID: 28323888
DOI: 10.1371/journal.pone.0174357
PMCID: PMC5360334

Genes

LZTS2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis.PMID 28323888Read ↗

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