Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT.

doi:10.1074/jbc.M206374200

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Article

Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT.

The Journal of biological chemistry - 14 Feb 2003

Liao Guoqing, Chen Liuh-Yow, Zhang Aihua, Godavarthy Aparna, Xia Fang, Ghosh Jagadish Chandra, Li Hui, Chen J Don

Abstract excerpt

Androgen receptor (AR) is a hormone-regulated transcription factor that mediates a wide array of biological processes including sexual differentiation, spermatogenesis, and prostate cancer progression. The transcriptional activity of AR and other members of the nuclear receptor superfamily are modulated by coregulatory proteins. In this study, we have investigated the regulation of AR transcriptional activity by...

Topics

DNA-Binding Proteins
Gene Expression Regulation
HeLa Cells
Humans
Mutation
Nuclear Receptor Co-Repressor 2
Receptors, Androgen
Recombinant Proteins
Repressor Proteins
Signal Transduction
Transcription, Genetic

Source

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Identifiers

PMID: 12441355
DOI: 10.1074/jbc.M206374200

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