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Article

Identification of βArrestin2 as a corepressor of androgen receptor signaling in prostate cancer

20 May 2009

Abstract excerpt

Androgen receptor (AR) signaling regulates the development and homeostasis of male reproductive organs, including the prostate. Deregulation of AR and AR coregulators, expression, or activity is involved in the initiation of prostate cancer and contributes to the transition of the disease to hormone-refractory stage. The ubiquitous betaArrestin proteins are now recognized as bona fide adapters and signal...

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PMID: 19458261
DOI: 10.1073/pnas.0900258106

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