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Article

Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.

The Journal of biological chemistry - 16 Jul 2004

Hartman Heather L, Bowers Katherine E, Fierke Carol A

Abstract excerpt

Protein geranylgeranyltransferase type I (GGTase I) catalyzes the attachment of a geranylgeranyl lipid group near the carboxyl terminus of protein substrates. Unlike protein farnesyltransferase (FTase) and protein geranylgeranyltransferase type II, which require both Zn(II) and Mg(II) for maximal turnover, GGTase I turnover is dependent only on Zn(II). In FTase, the magnesium ion is coordinated by aspartate...

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Identifiers

PMID: 15131129
DOI: 10.1074/jbc.M403469200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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