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Article

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011

Xiao Junyu, Engel James L, Zhang Ji, Chen Mark J, Manning Gerard, Dixon Jack E

Abstract excerpt

PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. We recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. To gain further insights into the molecular basis of PTPMT1 function, we determined the crystal structures of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21730175
DOI: 10.1073/pnas.1109290108
PMCID: PMC3142007

Genes

PTPMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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