Article

A somatic multiple myeloma mutation unravels a mechanism of oligomerization-mediated product inhibition in GGPPS

2024-12-25

Abstract excerpt

Protein prenylation regulates the cellular localization of small GTPases and is pivotal for multiple myeloma (MM) pathology. Geranylgeranyl diphosphate synthase (GGPPS), synthesizing a prenylation moiety, exhibits dimeric or hexameric stoichiometry in different species. However, the functional significance of this divergence remains elusive. Focusing on the hexameric human paralog, formed by trimer-of-dimers, we u...

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Literature Corpus work: 87dac976-a7f1-5387-99ad-ce306334a0ea
DOI: 10.1101/2024.12.25.628878

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