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Article

Functional evaluation of conserved basic residues in human phosphomevalonate kinase.

Biochemistry - 23 Oct 2007

Herdendorf Timothy J, Miziorko Henry M

Abstract excerpt

Phosphomevalonate kinase (PMK) catalyzes the cation-dependent reaction of mevalonate 5-phosphate with ATP to form mevalonate 5-diphosphate and ADP, a key step in the mevalonate pathway for isoprenoid/sterol biosynthesis. Animal PMK proteins belong to the nucleoside monophosphate (NMP) kinase family. For many NMP kinases, multiple basic residues contribute to the neutralization of the negatively charged...

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Identifiers

PMID: 17902708
DOI: 10.1021/bi701408t
PMCID: PMC2530820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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