Article
Loss of WWOX expression in gastric carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2004
Aqeilan Rami I, Kuroki Tamotsu, Pekarsky Yuri, Albagha Omar, Trapasso Francesco, Baffa Raffaele, Huebner Kay, Edmonds Pamela, Croce Carlo M
Abstract excerpt
PURPOSE: WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox. EXPERIMENTAL DESIGN: Loss of heterozygosity,...
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