Article
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2004
Kuroki Tamotsu, Yendamuri Sai, Trapasso Francesco, Matsuyama Ayumi, Aqeilan Rami I, Alder Hansjuerg, Rattan Shashi, Cesari Rossano, Nolli Maria L, Williams Noel N, Mori Masaki, Kanematsu Takashi, Croce Carlo M
Abstract excerpt
PURPOSE: WWOX (WW domain containing oxidoreductase) is a tumor suppressor gene that maps to the common fragile site FRA16D. We showed previously that WWOX is frequently altered in human lung and esophageal cancers. The purpose of this study was to delineate more precisely the role of WWOX in pancreatic carcinogenesis. EXPERIMENTAL DESIGN: We analyzed 15 paired pancreatic adenocarcinoma samples and 9 pancreatic...
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