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Article

WWOX in biological control and tumorigenesis

26 Apr 2007

Abstract excerpt

The WW domain-containing oxidoreductase (WWOX) gene is located at 16q23.1-16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N-terminal WW domains and a central short chain oxidoreductase-like domain. In the last few years, considerable amount of data have shown inactivation of WWOX in a variety of human malignancies. Moreover, interacting partners have...

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PMID: 17458891
DOI: 10.1002/jcp.21099

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