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Article

Genetic alterations of the WWOX gene in breast cancer.

Medical oncology (Northwood, London, England) - 1 Sept 2012

Ekizoglu Seda, Muslumanoglu Mahmut, Dalay Nejat, Buyru Nur

Abstract excerpt

FRA3B and FRA16D are the most sensitive common chromosomal fragile site loci in the human genome and two tumor suppressor genes FHIT (Fragile Histidine Triad) and WWOX (WW domain-containing oxidoreductase gene) map to this sites. The WWOX gene is composed of 9 exons and encodes a 46-kD protein that contains 414 amino acids. Loss of heterozygosity, homozygous deletions, and chromosomal translocations affecting...

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Source

Identifiers

PMID: 21983861
DOI: 10.1007/s12032-011-0080-0

Genes

WWOX
FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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