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Article

Targeted deletion of Wwox reveals a tumor suppressor function.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Aqeilan Rami I, Trapasso Francesco, Hussain Sadiq, Costinean Stefan, Marshall Dean, Pekarsky Yuri, Hagan John P, Zanesi Nicola, Kaou Mohamed, Stein Gary S, Lian Jane B, Croce Carlo M

Abstract excerpt

The WW domain-containing oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in several types of human cancer. We have previously shown that restoration of WWOX expression in cancer cells suppresses tumorigen...

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Source

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Identifiers

PMID: 17360458
DOI: 10.1073/pnas.0609783104
PMCID: PMC1820689

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Targeted deletion of Wwox reveals a tumor suppressor function.PMID 17360458Read ↗

WWOX: a fragile tumor suppressor.Semantic proximity Read ↗

WWOX in biological control and tumorigenesisSemantic proximity Read ↗

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Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.Semantic proximity Read ↗

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.Semantic proximity Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.Semantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.Semantic proximity Read ↗

Wwox inactivation enhances mammary tumorigenesis.Semantic proximity Read ↗

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.Semantic proximity Read ↗

Characterization of the tumor suppressor gene <i>WWOX</i> in primary human oral squamous cell carcinomasSemantic proximity Read ↗

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