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Article

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.

Cell death & disease - 6 Aug 2018

Abdeen Suhaib K, Ben-David Uri, Shweiki Aya, Maly Bella, Aqeilan Rami I

Abstract excerpt

Inactivation of WW domain-containing oxidoreductase (WWOX), the gene product of the common fragile site FRA16D, is a common event in breast cancer and is associated with worse prognosis of triple-negative breast cancer (TNBC) and basal-like breast cancer (BLBC). Despite recent progress, the role of WWOX in driving breast carcinogenesis remains unknown. Here we report that ablation of Wwox in mammary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 30082886
DOI: 10.1038/s41419-018-0896-z
PMCID: PMC6079009

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.PMID 30082886Read ↗

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Targeted deletion of Wwox reveals a tumor suppressor function.Semantic proximity Read ↗

Wwox inactivation enhances mammary tumorigenesis.Semantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis.Semantic proximity Read ↗

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.Semantic proximity Read ↗

Molecular Functions of WWOX Potentially Involved in Cancer DevelopmentSemantic proximity Read ↗

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.Semantic proximity Read ↗

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.Semantic proximity Read ↗

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