Article
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
Molecular cancer research : MCR - 1 Nov 2003
Ishii Hideshi, Vecchione Andrea, Furukawa Yutaka, Sutheesophon Krittaya, Han Shuang-Yin, Druck Teresa, Kuroki Tamotsu, Trapasso Francesco, Nishimura Miki, Saito Yasushi, Ozawa Keiya, Croce Carlo M, Huebner Kay, Furukawa Yusuke
Abstract excerpt
The WW domain containing oxidoreductase (WWOX) gene was recently identified as a candidate tumor suppressor gene at a common fragile site, FRA16D. Because the fragile histidine triad (FHIT) gene, a tumor suppressor gene encompassing the most active, common fragile site FRA3B, is frequently deleted in various cancers, we evaluated the expression of WWOX and FHIT in 74 cases of primary hematopoietic neoplasias and...
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