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Article

WWOX: a fragile tumor suppressor.

Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2015

Schrock Morgan S, Huebner Kay

Abstract excerpt

WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3-q24.1, spanning chromosomal fragile site FRA16D, encodes the 46 kDa Wwox protein, a tumor suppressor that is lost or reduced in expression in a wide variety of cancers, including breast, prostate, ovarian, and lung. The function of Wwox as a tumor suppressor implies that it serves a function in the prevention of carcinogenesis....

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Share to Carcinogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25538133
DOI: 10.1177/1535370214561590
PMCID: PMC4471953

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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WWOX: a fragile tumor suppressor.PMID 25538133Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

Targeted deletion of Wwox reveals a tumor suppressor function.Semantic proximity Read ↗

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WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.Semantic proximity Read ↗

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.Semantic proximity Read ↗

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.Semantic proximity Read ↗

WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis.Semantic proximity Read ↗

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.Semantic proximity Read ↗

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.Semantic proximity Read ↗

Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D.Semantic proximity Read ↗

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