Article
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Sept 2006
Lee Jong Woo, Kim Mee Ran, Soung Young Hwa, Nam Suk Woo, Kim Sang Ho, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
Failure of apoptosis is one of the hallmarks of cancer. As an execution-phase caspase, caspase-6 plays a crucial role during apoptosis. To explore the possibility that the genetic alterations of CASP, which encodes caspase-6, might be involved in the development of human cancers, we analyzed the entire coding region and all splice sites of the human CASP6 gene for the detection of somatic mutations in 100...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.