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Article

The GDP-bound form of Arf6 is located at the plasma membrane.

Journal of cell science - 1 May 2004

Macia Eric, Luton Frédéric, Partisani Mariagrazia, Cherfils Jacqueline, Chardin Pierre, Franco Michel

Abstract excerpt

The function of Arf6 has been investigated largely by using the T27N and the Q67L mutants, which are thought to be blocked in GDP- and GTP-bound states, respectively. However, these mutants have been poorly characterized biochemically. Here, we found that Arf6(T27N) is not an appropriate marker of the inactive GDP-bound form because it has a high tendency to lose its nucleotide in vitro and to denature. As a...

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Identifiers

PMID: 15126638
DOI: 10.1242/jcs.01090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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