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Article

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant.

Molecular and cellular biology - 1 Aug 2000

Al-Awar O, Radhakrishna H, Powell N N, Donaldson J G

Abstract excerpt

The ADP-ribosylation factor 6 (ARF6) GTPase has a dual function in cells, regulating membrane traffic and organizing cortical actin. ARF6 activation is required for recycling of the endosomal membrane back to the plasma membrane (PM) and also for ruffling at the PM induced by Rac. Additionally, ARF6 at the PM induces the formation of actin-containing protrusions. To identify sequences in ARF6 that are necessary...

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Source

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Identifiers

PMID: 10913182
DOI: 10.1128/MCB.20.16.5998-6007.2000
PMCID: PMC86076

Genes

ARF6
ARF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant.PMID 10913182Read ↗

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