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Article

A regulatory role for ARF6 in receptor-mediated endocytosis.

Science (New York, N.Y.) - 24 Feb 1995

D'Souza-Schorey C, Li G, Colombo M I, Stahl P D

Abstract excerpt

Adenosine diphosphate-ribosylation factor 6 (ARF6), ARF6 mutants, and ARF1 were transiently expressed in Chinese hamster ovary cells, and the effects on receptor-mediated endocytosis were assessed. Overexpressed ARF6 localized to the cell periphery and led to a redistribution of transferrin receptors to the cell surface and a decrease in the rate of uptake of transferrin. Similar results were obtained when a...

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Source

Identifiers

PMID: 7855600
DOI: 10.1126/science.7855600

Genes

ARF6
ARF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A regulatory role for ARF6 in receptor-mediated endocytosis.PMID 7855600Read ↗

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ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells.Semantic proximity Read ↗

Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport.Semantic proximity Read ↗

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant.Semantic proximity Read ↗

Role of ARF4L in recycling between endosomes and the plasma membrane.Semantic proximity Read ↗

The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.Semantic proximity Read ↗

ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation.Semantic proximity Read ↗

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.Semantic proximity Read ↗

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.Semantic proximity Read ↗

ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages.Semantic proximity Read ↗

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