Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting.

Molecular and cellular biology - 1 Dec 1999

Zhang Q, Calafat J, Janssen H, Greenberg S

Abstract excerpt

Activation of Rac1, a member of the Rho family of GTPases, is associated with multiple cellular responses, including membrane ruffling and focal complex formation. The mechanisms by which Rac1 is coupled to these functional responses are not well understood. It was recently shown that ARF6, a GTPase implicated in cytoskeletal alterations and a membrane recycling pathway, is required for Rac1-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factor 6
Share to ADP-Ribosylation Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to cdc42 GTP-Binding Protein

Share to Cytoskeleton

Share to Guanine Nucleotides

Share to Macrophage Colony-Stimulating Factor

Share to rac1 GTP-Binding Protein

Share to Subcellular Fractions

Source

Open in PubMed Open full text

Identifiers

PMID: 10567541
DOI: 10.1128/MCB.19.12.8158
PMCID: PMC84900

Genes

ARF6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting.PMID 10567541Read ↗

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant.Semantic proximity Read ↗

A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.Semantic proximity Read ↗

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.Semantic proximity Read ↗

ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages.Semantic proximity Read ↗

Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation.Semantic proximity Read ↗

A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis.Semantic proximity Read ↗

Arf6 Regulates Endocytosis and Angiogenesis by Promoting Filamentous Actin AssemblySemantic proximity Read ↗

Arf6 and its role in cytoskeletal modulation.Semantic proximity Read ↗

An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells.Semantic proximity Read ↗

ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation.Semantic proximity Read ↗

A regulatory role for ARF6 in receptor-mediated endocytosis.Semantic proximity Read ↗

ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.