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Mitochondrial DNA Copy Number and Risk of Oral Cancer: A Report from Northeast India

4 Mar 2013

Abstract excerpt

BACKGROUND: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer globally. Tobacco consumption and HPV infection, both are the major risk factor for the development of oral cancer and causes mitochondrial dysfunction. Genetic polymorphisms in xenobiotic-metabolizing enzymes modify the effect of environmental exposures, thereby playing a significant role in gene-environment interactions and hence...

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PMID: 23469236
DOI: 10.1371/journal.pone.0057771

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