Article
Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients.
Annals of the New York Academy of Sciences - 1 Apr 2004
Nomiyama Takashi, Tanaka Yasushi, Piao Lianshan, Hattori Nobutaka, Uchino Hiroshi, Watada Hirotaka, Kawamori Ryuzo, Ohta Shigeo
Abstract excerpt
A point mutation of mitochondrial DNA at nucleotide position 3243 A to G is responsible for the genetic cause of diabetes. Otherwise, this mutation is also reported to occur as a somatic mutation, possibility because of oxidative stress. Because diabetes may cause oxidative stress, we hypothesized that accumulation of the somatic A3243G mutation in mitochondrial DNA may be accelerated by diabetes. DNA was...
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