Article
High prevalence of mitochondrial diabetes mellitus in Japanese patients with major risk factors.
Metabolism: clinical and experimental - 1 Jul 1997
Fukui M, Nakano K, Obayashi H, Kitagawa Y, Nakamura N, Mori H, Kajiyama S, Wada S, Fujii M, Yoshimori K, Kanaitsuka T, Shigeta H, Kondo M
Abstract excerpt
To identify diabetes mellitus caused by the mitochondrial gene substitution at genomic nucleotide pair 3243 (M3243A-->G) we selected 87 diabetic patients with high risk factors such as maternal inheritance and hearing loss. Total DNA was extracted from peripheral leukocytes, and mitochondrial DNA fragments containing M3243A-->G were amplified by polymerase chain reaction (PCR). The amplified fragments were...
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