Article
Mutations of mitochondrial DNA in atherosclerosis and atherosclerosis-related diseases.
Current pharmaceutical design - 1 Jan 2015
Sobenin Igor A, Zhelankin Andrey V, Mitrofanov Konstantin Y, Sinyov Vasily V, Sazonova Margarita A, Postnov Anton Y, Orekhov Alexander N
Abstract excerpt
Atherosclerosis, the primary cause of cardiovascular disease, is a complex and multifactorial pathology resulted from the harmful interactions between genetic and environmental factors. There is a growing body of evidence in support of the role of mitochondrial factors in the pathogenesis of atherosclerosis. Impaired mitochondrial function and structural and qualitative changes in mitochondrial components such as...
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