Article
Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage.
Mutation research - 1 Jan 2003
Andreassi Maria Grazia
Abstract excerpt
Coronary artery disease (CAD) is a multifactorial process that appears to be caused by the interaction of environmental risk factors with multiple predisposing genes. Genetic research on CAD has traditionally focused on investigation aimed at identifying disease-susceptibility genes. Recent evidence suggests that somatically acquired DNA mutations may also contribute significantly to the pathogenesis of the...
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