Article
Markedly different clinical features in 2 diabetes mellitus patients with extremely high tissue levels of the mitochondrial DNA A3243G mutation.
Gerontology - 1 Jan 2008
Harihara Shinji, Nakamura Kenichi, Fujiwara Mutsunori, Arai Tomio, Sawabe Motoji, Takeuchi Fujio, Takubo Kaiyo
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) A3243G mutation is one of the major causative factors of mitochondrial diabetes mellitus. We found that tissues from 2 of 142 diabetes mellitus patients showed extremely high levels of the mutation. OBJECTIVE: To investigate the level of the mutation in each tissue and to find the relationship between the mutation level and clinical features of the patients. METHODS: Patient...
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