The tottering mouse: a critical review of its usefulness in the study of the neuronal mechanisms underlying epilepsy.

Abstract excerpt

The tottering mouse resulted from a recessively inherited, autosomal, single-locus mutation which produces a very characteristic neurological and cellular phenotype. Almost simultaneously and late in the development of this mutant appears a triad of symptoms: frequent episodes of absence seizures with spike-and-wave discharges; more rarely occurring episodes of focal motor seizures; and ataxia. Electrographic,...

Topics

• Action Potentials
• Animals
• Disease Models, Animal
• Electroencephalography
• Epilepsy
• Mice
• Mice, Neurologic Mutants
• Neurons
• Phenotype