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Article

Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1991

Helekar S A, Noebels J L

Abstract excerpt

A mutation at the tottering locus (tg, recessive, on chromosome 8) stimulates noradrenergic locus coeruleus axon terminal outgrowth and predisposes the brain to generalized spike-wave epilepsy in the young mouse. In an isolated synaptic circuit studied in vitro, the hyperinnervated mutant hippocampal pyramidal neurons respond normally when individually activated; however, latent neuronal signaling defects emerge...

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Identifiers

PMID: 2052555
DOI: 10.1073/pnas.88.11.4736
PMCID: PMC51741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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