Article
Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1991
Helekar S A, Noebels J L
Abstract excerpt
A mutation at the tottering locus (tg, recessive, on chromosome 8) stimulates noradrenergic locus coeruleus axon terminal outgrowth and predisposes the brain to generalized spike-wave epilepsy in the young mouse. In an isolated synaptic circuit studied in vitro, the hyperinnervated mutant hippocampal pyramidal neurons respond normally when individually activated; however, latent neuronal signaling defects emerge...
Topics
- Animals
- Electrophysiology
- Epilepsy
- Hippocampus
- In Vitro Techniques
- Membrane Potentials
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Mutation
- Neurons