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Article

Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering.

The Journal of physiology - 1 Mar 2003

Zhou Yu Dong, Turner Timothy J, Dunlap Kathleen

Abstract excerpt

Tottering, a mouse model for absence epilepsy and cerebellar ataxia, carries a mutation in the gene encoding class A (P/Q-type) Ca2+ channels, the dominant exocytotic Ca2+ channel at most synapses in the mammalian central nervous system. Comparing tottering to wild-type mice, we have studied glutamatergic transmission between parallel fibres and Purkinje cells in cerebellar slices. Results from biochemical assays...

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Identifiers

PMID: 12562906
DOI: 10.1113/jphysiol.2002.033415
PMCID: PMC2342657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering.PMID 12562906Read ↗

Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering.Semantic proximity Read ↗

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Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel.Semantic proximity Read ↗

L-type calcium channels contribute to the tottering mouse dystonic episodes.Semantic proximity Read ↗

The tottering mouse: a critical review of its usefulness in the study of the neuronal mechanisms underlying epilepsy.Semantic proximity Read ↗

Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels.Semantic proximity Read ↗

An ultrastructural study of granule cell/Purkinje cell synapses in tottering (tg/tg), leaner (tg(la)/tg(la)) and compound heterozygous tottering/leaner (tg/tg(la)) mice.Semantic proximity Read ↗

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.Semantic proximity Read ↗

Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.Semantic proximity Read ↗

Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal NeuronsSemantic proximity Read ↗

Decreased gene expression of calretinin and ryanodine receptor type 1 in tottering mice.Semantic proximity Read ↗

Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami.Semantic proximity Read ↗

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