Article
Striatal expression of Homer1a is affected by genotype but not dystonic phenotype of tottering mice: a model of spontaneously occurring motor disturbances.
Neuroscience letters - 10 Oct 2011
Iasevoli Felice, Cicale Maria, Abbott Louise C, de Bartolomeis Andrea
Abstract excerpt
Tottering (tg) mice carry a missense mutation in the gene coding for P/Q-type voltage-dependent Ca(2+) channels (VDCCs). Aberrant functioning of P/Q-type VDCCs results in molecular alterations in Ca(2+) currents and in glutamate and dopamine systems. As a consequence, tottering mice exhibit mild ataxia, spontaneous epilepsy, and paroxysmal dyskinesia. In this study, we evaluated whether the tottering mice...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.