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Article

Animal models for autosomal dominant frontal lobe epilepsy: on the origin of seizures.

Expert review of neurotherapeutics - 1 Dec 2010

Steinlein Ortrud K

Abstract excerpt

Autosomal dominant frontal lobe epilepsy (ADNFLE) can be caused by mutations in either the α4 or β2 subunit of the neuronal nicotinic Ach receptor. In vitro expression studies in Xenopus oocytes or human embryonic kidney cells have been proven to be valuable tools for the characterization of these mutations, but they do not fully resemble the situation in vivo. Compared with them, animal models have the advantage...

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Identifiers

PMID: 21091316
DOI: 10.1586/ern.10.130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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