Article
Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Sept 2007
Teper Yaroslav, Whyte Douglas, Cahir Elizabeth, Lester Henry A, Grady Sharon R, Marks Michael J, Cohen Bruce N, Fonck Carlos, McClure-Begley Tristan, McIntosh J Michael, Labarca Cesar, Lawrence Andrew, Chen Feng, Gantois Ilse, Davies Philip J, Petrou Steven, Murphy Mark, Waddington John, Horne Malcolm K, Berkovic Samuel F, Drago John
Abstract excerpt
We generated a mouse line harboring an autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE) mutation: the alpha4 nicotinic receptor S248F knock-in strain. In this mouse, modest nicotine doses (1-2 mg/kg) elicit a novel behavior termed the dystonic arousal complex (DAC). The DAC includes stereotypical head movements, body jerking, and forelimb dystonia; these behaviors resemble some core features of ADNFLE....
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