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Article

Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine.

The Journal of clinical investigation - 1 May 2004

Iinuma Toshio, Homma Sadamu, Noda Tetsuo, Kufe Donald, Ohno Tsuneya, Toda Gotaro

Abstract excerpt

Here we describe the effect of immunization with dendritic cells loaded with syngeneic tumor cells (DC/Ts) by polyethylene glycol treatment, on tumor development in adenomatous polyposis coli (APC) gene mutant mouse models, APC1309 and APC(Min-/+), in which adenomatous polyps of the gastrointestinal tracts develop with a high incidence. Treatment with DC/Ts prevented the development of gastrointestinal tumors,...

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Identifiers

PMID: 15124022
DOI: 10.1172/JCI17323
PMCID: PMC398422

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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