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Article

Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Dec 2016

Tanner Scott M, Daft Joseph G, Hill Stephanie A, Martin Colin A, Lorenz Robin G

Abstract excerpt

The adenomatous polyposis coli (APC) gene is a known tumor suppressor gene, and mice with mutations in Apc (ApcMin/+) spontaneously form multiple intestinal neoplasms. In this model of human colorectal cancer (CRC), it has been reported that CD4+ T-cell-derived interleukin 17 (IL-17) promotes intestinal tumor development, but it is not known if the Apc mutation actually directly alters T-cell function and...

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Source

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Identifiers

PMID: 27798287
DOI: 10.1369/0022155416672418
PMCID: PMC5131745

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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