Article
Identification, design, and in vivo proof of concept of a shared APC neoantigen delivered via a self-amplifying RNA containing virus-like nanoparticle for cancer vaccination.
Frontiers in immunology - 1 Jan 2026
Simmons Alfred J, Nikonova Anna S, Jonas Chloe D, Pniewski Katherine A, Upreti Deepak, Perez Maria I, Adhikari Satish
Abstract excerpt
Colorectal Cancer (CRC) accounts for the second highest number of cancer-related mortalities rate worldwide, and its incidence and mortality is expected to continue to increase in the coming years. Over 80% of CRC cases are caused by mutation in the Adenomatous Polyposis Coli (APC) gene, a tumor suppressor gene involved in the Wnt signaling pathway that prevents uncontrolled cell growth. Familial Adenomatous...
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