Article
Chitosan nanoparticles as antigen vehicles to induce effective tumor specific T cell responses.
PloS one - 1 Jan 2020
Walter Frederik, Winter Elsa, Rahn Sascha, Heidland Judith, Meier Saskia, Struzek Anna-Maria, Lettau Marcus, Philipp Lisa-Marie, Beckinger Silje, Otto Lilli, Möller Julia Luisa, Helm Ole, Wesch Daniela, Scherließ Regina, Sebens Susanne
Abstract excerpt
Cancer vaccinations sensitize the immune system to recognize tumor-specific antigens de novo or boosting preexisting immune responses. Dendritic cells (DCs) are regarded as the most potent antigen presenting cells (APCs) for induction of (cancer) antigen-specific CD8+ T cell responses. Chitosan nanoparticles (CNPs) used as delivery vehicle have been shown to improve anti-tumor responses. This study aimed at...
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