Article
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations.
Frontiers in immunology - 1 Jan 2023
Cuche Céline, Mastrogiovanni Marta, Juzans Marie, Laude Hélène, Ungeheuer Marie-Noëlle, Krentzel Daniel, Gariboldi Maria Isabella, Scott-Algara Daniel, Madec Marianne, Goyard Sophie, Floch Camille, Chauveau-Le Friec Gaëlle, Lafaye Pierre, Renaudat Charlotte, Le Bidan Muriel, Micallef Christine, Schmutz Sandrine, Mella Sébastien, Novault Sophie, Hasan Milena, Duffy Darragh, Di Bartolo Vincenzo, Alcover Andrés
Abstract excerpt
Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the origin of this disease, as well as of a high percentage of spontaneous colorectal tumors. APC is therefore considered a tumor suppressor gene. While the role of...
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