Article
A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007
Chen Yu-Xiao, Man Kwan, Ling Guang Sheng, Chen Yichen, Sun Bai-Shun, Cheng Qiao, Wong On Hong, Lo Chi-Kin, Ng Irene Oi-Lin, Chan Li Chong, Lau George K, Lin Chen-Lung Steve, Huang Fanglu, Huang Fang-Ping
Abstract excerpt
The dendritic cell (DC)-based tumor immunotherapy has been a new promise of cure for cancer patients, but animal studies and clinical trials have thus far only shown limited success, especially in treating established tumors. Certain immunosuppressive mechanisms triggered by tumor cells or the derivatives are believed to be a major obstacle. We studied the role of DC-derived IL-10 and its negative impact on...
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