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Article

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein.

The Journal of experimental medicine - 29 Sept 2008

Cheng Pingyan, Corzo Cesar A, Luetteke Noreen, Yu Bin, Nagaraj Srinivas, Bui Marylin M, Ortiz Myrna, Nacken Wolfgang, Sorg Clemens, Vogl Thomas, Roth Johannes, Gabrilovich Dmitry I

Abstract excerpt

Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and leads to suppression of antitumor immune responses. The molecular mechanism of this phenomenon remains unclear. We report here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in...

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Identifiers

PMID: 18809714
DOI: 10.1084/jem.20080132
PMCID: PMC2556797

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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