Article

Preventive dendritic cell vaccination induced TGF-βRII frameshift neoantigen-specific T-cells are linked to long-term disease-free survival in Lynch Syndrome patients

2025-07-22

Abstract excerpt

<title>Abstract</title> <p>Despite compliance to surveillance colonoscopies, patients with Lynch Syndrome (LS) remain at a substantial lifetime risk of developing colorectal cancer, with rates as high as 30–52%. This highlights the need for better cancer prevention strategies. To assess the safety, feasibility, and immunogenicity of a preventive (neo)antigen-based dendritic cell (DC) vaccine, a phase I/II clinica...

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Literature Corpus work: 9fd79987-0042-543e-8b27-79e19e391a4e
DOI: 10.21203/rs.3.rs-6718232/v1

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