Article
Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice.
Cancer science - 1 Dec 2007
Yokomine Kazunori, Nakatsura Tetsuya, Senju Satoru, Nakagata Naomi, Minohara Motozumi, Kira Jun-Ichi, Motomura Yutaka, Kubo Tatsuko, Sasaki Yutaka, Nishimura Yasuharu
Abstract excerpt
Heat shock protein (HSP) 105 is overexpressed in various cancers, but is expressed at low levels in many normal tissues, except for the testis. A vaccination with HSP105-pulsed bone marrow-derived dendritic cells (BM-DC) induced antitumor immunity without causing an autoimmune reaction in a mouse model. Because Apc(Min/+) mice develop multiple adenomas throughout the intestinal tract by 4 months of age, the mice...
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