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Article

Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.

The Journal of biological chemistry - 26 Mar 2004

Bayle Julie, Letard Sébastien, Frank Ronald, Dubreuil Patrice, De Sepulveda Paulo

Abstract excerpt

Suppressor of cytokine signaling (SOCS) proteins are a family of Src homology 2-containing adaptor proteins. Cytokine-inducible Src homology domain 2-containing protein, SOCS1, SOCS2, and SOCS3 have been implicated in the down-regulation of cytokine signaling. The function of SOCS4, 5, 6, and 7 a...

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Source

Identifiers

PMID: 14707129
DOI: 10.1074/jbc.M313381200

Genes

KIT
SOCS6
SOCS1
SOCS2
SOCS3
SOCS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14707129-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.PMID 14707129Read ↗

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Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT PathwaysSemantic proximity Read ↗

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.Semantic proximity Read ↗

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SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation.Semantic proximity Read ↗

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