Article

The inhibition of FKBP5 protects β cell survival under inflammation stress via AKT/FOXO1 signaling.

2023-02-07

Abstract excerpt

The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and as a potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). However, in β cells, which secrete the only glucose-lowering hormone—insulin, the expression and function of FKBP5 has not been documented. Here, using human pancreatic tissue and...

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Literature Corpus work: cc4eb6b1-886b-5b27-a92f-5b5664e97d5e
DOI: 10.21203/rs.3.rs-2490021/v1

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