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Article

Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway.

Endocrinology - 1 Oct 1997

Ceresa B P, Horvath C M, Pessin J E

Abstract excerpt

We recently reported that insulin stimulation results in the serine phosphorylation of STAT3 (signal transducer and activator of transcription-3). In the present study, we identified serine 727 as the site of insulin-stimulated STAT3 serine phosphorylation. This phosphorylation event occurs independent of tyrosine phosphorylation. Furthermore, interleukin-6-induced tyrosine phosphorylation can occur independent...

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Source

Identifiers

PMID: 9322921
DOI: 10.1210/endo.138.10.5266

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway.PMID 9322921Read ↗

Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.Semantic proximity Read ↗

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.Semantic proximity Read ↗

Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases.Semantic proximity Read ↗

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.Semantic proximity Read ↗

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras.Semantic proximity Read ↗

Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.Semantic proximity Read ↗

Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.Semantic proximity Read ↗

SOCS-3 is an insulin-induced negative regulator of insulin signaling.Semantic proximity Read ↗

Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin.Semantic proximity Read ↗

Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells.Semantic proximity Read ↗

Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytesSemantic proximity Read ↗

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.Semantic proximity Read ↗

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