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Article

Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2009

Josephsen Kaj, Praetorius Jeppe, Frische Sebastian, Gawenis Lara R, Kwon Tae-Hwan, Agre Peter, Nielsen Søren, Fejerskov Ole

Abstract excerpt

Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining calcium homeostasis. The osteoclast creates an enclosed space, a lacuna, between their ruffled border membrane and the mineralized bone. They extrude H(+) and Cl(-) into these lacunae by the combined action of vesicular H(+)-ATPases and ClC-7 exchangers to dissolve the hydroxyapatite of bone...

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Identifiers

PMID: 19164575
DOI: 10.1073/pnas.0811682106
PMCID: PMC2635809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice.PMID 19164575Read ↗

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